Splenic irradiation in myelofibrosis. Clinical findings and ferrokinetics

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(77)90112-2· OSTI ID:6781780

Parmentier, C; Charbord, P; Tibi, M; Tubiana, M

Nine patients were submitted to splenic or, in two cases, hepatosplenic irradiation; these patients presented a primary myelofibrosis or a spent polycythemia vera characterized by splenomegaly, anemia, and occasionally leucocytosis and thrombocytopenia. The hematological condition returned to normal in 2 patients. This improvement lasted 4 years after a first series of irradiation. The recurrence of splenomegaly and anemia indicated a second series of irradiation, the results of which were as good as those of the first series. Ineffective medullary and splenic erythropoiesis without preeminent aplasia appeared to be correlated with a beneficial effect of splenic irradiation. Absence of hepatomegaly and marked leucocytosis were less important prognostic factors. The modee of action of radiotherapy and the way in which it differs from splenectomy are discussed. The irradiation delivered moderate doses (450 rad in 18 sessions of 25 rad). Hepatic irradiation did not appear to be essential even in cases of intense hepatic myeloid metaplasia: in 2 patients liver erythropoiesis regressed when the spleen alone was irradiated.

• Research Organization: Unite de Medecine Nucleaire de l'Institut Gustave-Roussy, Villejuif, France
• OSTI ID: 6781780
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 2:11-12; ISSN IOBPD
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCOPAL RADIATION EFFECTS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BLOOD VESSELS
BODY
BONE MARROW CELLS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE CELLS
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ERYTHROPOIESIS
FIBROSIS
FRACTIONATED IRRADIATION
HEMIC DISEASES
HYPERTENSION
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
LOCAL IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
POLYCYTHEMIA
PORTAL SYSTEM
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
SPLEEN
SYMPTOMS
THERAPY
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VEINS