The importance of sex-specific quantitative criteria in thallium-201 myocardial scintigraphy

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6844630

Rabinovitch, M A; Suissa, S; Elstein, J; Turek, M; Addas, A; Burgess, J H; Rosenthall, L

Breast attenuation is an important cause of artifactual cold spots on visually interpreted TL-201 myocardial images. This study was undertaken to determine the need for sex-specific criteria in the quantitative analysis of exercise-redistribution TL-201 myocardial scintigraphy (SCINT). The studies of 13 normal females (F) and 12 normal males (M) were processed according to the method of a previous study. Significant sexual differences were found in 7/12 regional uptake (U) proportions, 9/11 regional washout (WO) percentages, 0/3 image redistribution indices, and 0/1 lung to heart ratio. The differences primarily reflected a proportionately decreased anterior and septal uptake in F, a proportionately decreased inferior and inferoapical U in M, and faster WO in F. Sex-specific and total population normal boundaries were set a +- 3SD of the mean for each parameter. Sex-specific boundaries were narrower, and, for 5 parameters (4U and 1WO), contained within the total population boundaries. It was estimated that these differences in boundaries would result in a 6 to 25% discrepancy in patient classification. These results predict that a subset of M and F with coronary artery stenoses could be misclassified as normal by total population criteria, while properly classified as abnormal by sex-specific criteria. The authors conclude that since important differences exist between M and F in the detected pattern of TL-201 myocardial U and WO, sex-specific cr4iteria may enhance the predictive accuracy of SCINT.

• Research Organization: Montreal General Hospital, McGill Univ., Montreal, Quebec
• OSTI ID: 6844630
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ATTENUATION
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CLASSIFICATION
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
FEMALES
GLANDS
HEART
HEAVY NUCLEI
IMAGES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MALES
MAMMARY GLANDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SEX DEPENDENCE
THALLIUM 201
THALLIUM ISOTOPES
USES