Radiolabelled spiroperidol: Possible pituitary adenoma imaging agent

Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:6844337

Otto, C A; Marshall, J C; Lloyd, R V; Sherman, P S; Wieland, D M

Prolactin-secreting pituitary adenomas are the most common type of pituitary tumors. Detection currently depends on physical symptoms, elevated serum prolactin levels and CT scans. An imaging agent which specifically localized in prolactinomas based on some functional characteristic of the tumor would be of considerable clinical value not only for early detection but also for monitoring of therapy. Tritiated spiroperidol (/sup 3/H-Sp) was selected for evaluation based on 1) the presence of D-2 receptors in normal anterior pituitary and adenoma tissue and 2) the high affinity of spiroperidol for D-2 receptors. Recent data have established that implantation of diethylstilbestrol (DES) in Fischer F344 rats induced prolactin-secreting tumors in the pituitary. /sup 3/HSp was evaluated in pituitary tissue of both control and DES-treated rats. /sup 3/HSp concentration in normal female anterior pituitary tissue was found to be about 0.27% kg dose/g from 5 min to 4hrs. This value was about 10 times levels in cortex, cerebellum and striatum. In DES-treated rats the % kg dose/g values remained approximately the same. A 5-fold increase in serum prolactin was associated with a 6-fold increase in both pituitary weight and % dose/organ. The data suggests that although total pituitary weight has increased due to tumor growth (reflected in increased values for % dose/organ), the relative number of receptors per g of tissue has remained constant. This result is in agreement with observations of others on D-2 receptor concentration in prolactinomas.

• Research Organization: Univ. of Michigan-Dearborn, Dearborn, MI
• OSTI ID: 6844337
• Report Number(s): CONF-840619-
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BLOOD CHEMISTRY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRAL CORTEX
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
FEMALES
GLANDS
GONADOTROPINS
HORMONES
IMAGE PROCESSING
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LTH
MAMMALS
MEMBRANE PROTEINS
MONITORING
NEOPLASMS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
PROCESSING
PROTEINS
QUANTITY RATIO
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
SYMPTOMS
THERAPY
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
USES
VERTEBRATES