Radiation response of the canine cardiovascular system

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575726· OSTI ID:6841991

Gavin, P R ^[1]; Gillette, E L

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1. Washington State Univ., Pullman

The hearts of dogs were irradiated with /sup 60/Co ..gamma.. rays. The dose required to produce pericardial effusion in 50% of the dogs by 180 days (PED/sub 50///sub 180/) was 1220 rad. For cardiac tamponade, the CTD /sub 50///sub 180/ was 1500 rad. Morphometric analyses of the hearts showed decreased capillary volume and increased fibrosis as radiation dose increased. The pericardial thickness increased with increased radiation dose. The slopes of the dose response for these parameters were similar as determined by linear regression of the parameter versus radiation dose.

• OSTI ID: 6841991
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 90:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
COBALT 60
COBALT ISOTOPES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
FIBROSIS
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORPHOLOGICAL CHANGES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIVITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES