Survival of primates following orthotopic cardiac transplantation treated with total lymphoid irradiation and chemical immune suppression

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198112000-00003· OSTI ID:6841892

Pennock, J L; Reitz, B A; Bieber, C P; Aziz, S; Oyer, P E; Strober, S; Hoppe, R; Kaplan, H S; Stinson, E B; Shumway, N E

Fractionated total lymphoid irradiation (TLI) has been used for attempts at induction of a donor-specific tolerant-like state in allograft recipients and for immunosuppressive effects. Cyclosporin A (Cy A) has been shown to suppress rejection of organ grafts in many species including man. The present study was designed to test the effectiveness of TLI in combination with either CY A or rabbit anticynomolgus thymocyte globulin (ATG) and azathioprine. Thirty-one orthotopic cardiac allografts were performed using surface cooling and total circulatory arrest in outbred cynomolgus monkeys. TLI was administered preoperatively in fractions of 100 rad until a total of 600 or 1800 rad was achieved. Cy A was administered 17 mg/kg/day. All treatment groups demonstrated extended survival. Myocardial biopsies as early as 4 weeks were consistent with mild rejection in all treatment groups. No significant synergistic effect upon survival could be demonstrated utilizing TLI plus Cy A when compared with using Cy A alone. TLI (1800 rad) plus ATG and azathioprine was associated with a high incidence of early death attributable to leukopenia and infection. Cy A alone or in combination with TLI was associated with the development of lymphoid malignancy.

• Research Organization: Department of Cardiovascular Surgery, Stanford University School of Medicine, CA
• OSTI ID: 6841892
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 32:6; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CHEMOTHERAPY
DOSES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GRAFT-HOST REACTION
GRAFTS
HEART
IMMUNOSUPPRESSION
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MONKEYS
ORGANS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
THERAPY
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION