The effect of topical dexamethasone and preoperative beta irradiation on a model of glaucoma fistulizing surgery in the rabbit
- Institute of Ophthalmology, London (England)
We studied the effect of topical dexamethasone (1%) and preoperative beta irradiation on a model of glaucoma fistulizing surgery in the rabbit. Intraocular pressure and gross facility of aqueous outflow following surgery were not influenced by either treatment, although blebs persisted longer in the irradiated eyes. Steroids reduced clinically observable inflammation as well as the number of inflammatory cells identifiable by microscopy. Fibroblast production temporarily slowed, and ultrastructural examination demonstrated lipid-filled vacuoles and dilated mitochondria in these eyes. Also, the scar was thinner at 24 days. Beta irradiation delayed wound healing and the scar was thinner in the early postoperative stages, but the light microscopic appearance of the scar was unaltered at 59 days. Inflammation was more pronounced initially, with abundant fibrin in the wound. Recovery of the conjunctival epithelium was delayed. The delay in fibroblast recruitment and wound contraction, the thinner scar tissue, and the increased survival of the bleb are all factors that suggest that beta irradiation may be a useful adjunct to glaucoma surgery.
- OSTI ID:
- 6833277
- Journal Information:
- Ophthalmic Surgery; (USA), Vol. 21:1; ISSN 0022-023X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EYES
ULTRASTRUCTURAL CHANGES
WOUNDS
HEALING
BETA PARTICLES
BIOLOGICAL RADIATION EFFECTS
DEXAMETHASONE
EPITHELIUM
FIBROBLASTS
INFLAMMATION
MITOCHONDRIA
RABBITS
SENSE ORGANS DISEASES
STEROIDS
SURGERY
ADRENAL HORMONES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
BODY AREAS
CELL CONSTITUENTS
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
DISEASES
FACE
GLUCOCORTICOIDS
HEAD
HYDROXY COMPOUNDS
INJURIES
KETONES
MAMMALS
MEDICINE
MORPHOLOGICAL CHANGES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANES
RADIATION EFFECTS
RECOVERY
SENSE ORGANS
SOMATIC CELLS
SYMPTOMS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals