Kidney and lung injury in irradiated rats protected from acute death by partial-body shielding

Journal Article · Sat Mar 31 23:00:00 EST 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577588· OSTI ID:6833247

Geraci, J P; Jackson, K L; Mariano, M S; Michieli, B M ^[1]

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1. Univ. of Washington, Seattle (USA)

Ninety-six CD-1 male rats were exposed to gamma-ray doses (0-25 Gy) in increments of 5 Gy. One femur, the surgically exteriorized GI tract, and the oral cavity were shielded during irradiation to protect against acute mortality from injury to the hematopoietic system, small intestine, and oral cavity. In addition, the thoraxes of half of the animals from each dose group were shielded. At approximately monthly intervals from 2 to 10 months after irradiation the hematocrit, plasma urea nitrogen (PUN), and {sup 51}Cr-EDTA clearance were measured. During the study 20 thorax-shielded and 19 thorax-irradiated animals died. All rats whose thoraxes received 25 Gy irradiation and three out of seven rats whose thoraxes received 20 Gy died 1 to 3 months postirradiation with massive pleural fluid accumulation. Shielding the thoraxes prevented this mode of death at these doses. Kidney injury was judged to be the primary cause of death of all thorax-shielded animals and 15- and 20-Gy thorax-irradiated animals. Animals with kidney damage had elevated PUN and reduced {sup 51}Cr-EDTA clearance and hematocrits. The relative merits of each of these end points in assessing radiation-induced kidney injury after total-body exposure are discussed.

• OSTI ID: 6833247
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 122:1; ISSN 0033-7587; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550901 -- Pathology-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEST
CHROMIUM 51
CHROMIUM ISOTOPES
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
EDTA
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
FEMUR
GAMMA RADIATION
GASTROINTESTINAL TRACT
INJURIES
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LUNGS
MAMMALS
NUCLEI
ORAL CAVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIATIONS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SKELETON
TRACER TECHNIQUES
VERTEBRATES
WHOLE-BODY IRRADIATION