Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption
- Centers for Disease Control, Atlanta, GA (USA)
Chromosome fragility in 96 h, low-folate cultures was found to be associated with smoking status, coffee consumption, and blood folate level. The higher proportion of cells with chromosome aberrations in cigarette smokers was attributable to lower red cell folate levels in smokers compared with nonsmokers. There was a positive linear relationship between the average cups of coffee consumed per day and the proportion of cells with aberrations. This association was independent of the effects of smoking and red cell folate level. These data suggest that smoking history, coffee consumption, and red cell folate level are important considerations for the design and interpretation of fragile site studies in cancer cytogenetics.
- OSTI ID:
- 6833027
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 13:4; ISSN EMMUE; ISSN 0893-6692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINO ACIDS
AROMATICS
AZAARENES
BEVERAGES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMISTRY
CHROMOSOMAL ABERRATIONS
COFFEE BEANS
COLLOIDS
CYTOLOGY
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ERYTHROCYTES
FOLIC ACID
FOOD
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MATERIALS
MUTATION FREQUENCY
MUTATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PTERIDINES
RESIDUES
SEEDS
SMOKES
SOLS
TOBACCO SMOKES
VITAMIN B GROUP
VITAMINS