Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effect of cigarette smoke on human serum trypsin inhibitory capacity and antitrypsin concentration

Journal Article · · Am. Rev. Respir. Dis.; (United States)
OSTI ID:6711840
; ; ;
Investigation of the effect of cigarette smoke on the serum trypsin inhibitory capacity (TIC) and antitrypsin content in 89 smokers compared with 37 nonsmokers revealed that cigarette smoking is associated with a significantly lower level of TIC. No alteration in serum antitrypsin content was found because of cigarette smoking. Further analysis of the data indicated a correlation between the magnitude of smoking and the reduction in serum TIC. The reduction of TIC in cigarette smokers is consistent with the recent findings of decreased alpha 1-antitrypsin activity in rat lung and the reduced elastase inhibitory capacity per mg of alpha 1-antitrypsin found in the serum of smokers. The decrease in TIC in the serum of smokers, in addition to the reported decrease in elastolytic activity, may be useful in explaining the pathogenesis of emphysema frequently found in smokers.
Research Organization:
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock
OSTI ID:
6711840
Journal Information:
Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 126:1; ISSN ARRDA
Country of Publication:
United States
Language:
English

Similar Records

Cigarette smoke inhalation decreases. cap alpha. /sub 1/-antitrypsin activity in rat lung
Journal Article · Thu Dec 13 23:00:00 EST 1979 · Science; (United States) · OSTI ID:5486638
Reduction of the elastase inhibitory capacity of alpha 1-antitrypsin by peroxides in cigarette smoke: an analysis of brands and filters
Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Am. Rev. Respir. Dis.; (United States) · OSTI ID:6711832
Inactivation of bronchial mucous proteinase inhibitor by cigarette smoke and phagocyte-derived oxidants
Journal Article · Fri Aug 01 00:00:00 EDT 1980 · Exp. Lung Res.; (United States) · OSTI ID:5610418

Related Subjects

550200 -- Biochemistry
550900 -- Pathology
551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BLOOD SERUM
COLLOIDS
DISEASES
DISPERSIONS
EMPHYSEMA
ENZYME ACTIVITY
ENZYMES
HYDROLASES
KINETICS
PATHOLOGY
PEPTIDE HYDROLASES
REACTION KINETICS
RESIDUES
RESPIRATORY SYSTEM DISEASES
SERINE PROTEINASES
SMOKES
SOLS
TOBACCO SMOKES
TRYPSIN