Multifractionation of /sup 60/Co gamma-rays reduces neoplastic transformation in vitro

Journal Article · Wed Feb 01 04:00:00 EST 1984 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/5.2.193· OSTI ID:6832448

Hill, C K; Han, A; Buonaguro, F; Elkind, M M

Incidences of neoplastic transformation of 10T 1/2 cells, derived from a C3H mouse embryo, were measured following irradiation of cells with /sup 60/Co gamma-rays delivered in single total doses, from 25 to 300 rads, or in different numbers of fractions and with different time intervals between fractions. Throughout the range of total doses that was examined (25-300 rads) exposure of asynchronous, actively growing 10T 1/2 cells to a dose of gamma-rays in five equal daily fractions, rather than in a single exposure, results in a significant reduction in transformation frequency. The initial part of the induction curve fits a straight line quite well. The slope of the line for five daily fractions is approximately 3-fold less steep than that for single exposures. A further increase in the interfraction interval, to 48 h, or further reductions in the dose per fraction, led to additional decreases in the incidence of neoplastic transformation. Our observations are consistent with a net 'error-free' repair of subtransformation damage as a result of protracted irradiation with /sup 60/Co gamma-rays.

• Research Organization: Division of Biological and Medical Research, Argonne National Laboratory, IL
• OSTI ID: 6832448
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5:2; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COBALT 60
COBALT ISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EMBRYONIC CELLS
FRACTIONATED IRRADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ONCOGENIC TRANSFORMATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES