Lifetime carcinogenesis studies of amosite asbestos (Case No. 121-72-73-5) in Syrian golden hamsters (feed studies). Technical report series

Technical Report · Tue Nov 01 04:00:00 EST 1983

OSTI ID:6831174

Carcinogenesis studies of amosite asbestos were conducted by administering diets containing 1% of the asbestos in pellets from the conception of the mothers through the lifetime of male and female Syrian golden hamsters. Control groups consisted of 127 male and 126 female hamsters and the amosite asbestos group consisted of 252 male and 254 female hamsters. No adverse effect on body-weight gain or survival was observed from treatment with amosite asbestos. Neither of the amosite asbestos groups showed increased neoplasia in any organ or tissue compared to the control groups. Under the conditions of these studies, the ingestion of amosite asbestos at a level of 1% in the diet for their lifetime was not toxic and did not cause a carcinogenic response in male and female Syrian golden hamsters.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 6831174
• Report Number(s): PB-87-133278/XAB; NTP-81-58
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
BIOASSAY
CARCINOGENESIS
HAMSTERS
LABORATORY ANIMALS
MAMMALS
PATHOGENESIS
RODENTS
VERTEBRATES