Lifetime carcinogenesis studies of chrysotile asbestos (CAS No. 12001-29-5) in syrian golden hamsters (feed studies). Technical report series

Technical Report · Sun Jul 01 04:00:00 EDT 1990

OSTI ID:5998187

Carcinogenesis studies of short range (SR), intermediate range (IR) or intermediate range chrysotile asbestos in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) were conducted with male and female Syrian golden hamsters. Both forms of chrysotile asbestos were administered at a concentration of 1% in pelleted diet for the entire lifetime of the hamsters, starting with mothers of the test animals. Group sizes varied from 125 to 253. Starting at 6 weeks of age, male and female hamsters in the intermediate range chrysotile/DMH study were given oral doses of DMH (4 mg/kg) every other week for a total of 5 doses. There was no adverse effect on body weight gain or survival by either form of asbestos or by asbestos in combination with DMH. Under the conditions of these studies, neither short range chrysotile nor intermediate range chrysotile asbestos was carcinogenic when ingested at 1% levels in the diet by male and female Syrian golden hamsters. While there were increases in the rates of adrenal cortical adenomas in male and female hamsters exposed to intermediate range chrysotile asbestos compared with pooled control groups, these incidence rates were not different when compared with the concurrent control groups. Additionally, the biologic importance of adrenal tumors in the absence of target organ (gastrointestinal tract) neoplasia is questionable.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 5998187
• Report Number(s): PB-91-142380/XAB; NTP-TR--246
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ADRENAL GLANDS
ANIMALS
ASBESTOS
BODY
CARCINOGENESIS
CARCINOGENS
DISEASES
DOCUMENT TYPES
ENDOCRINE GLANDS
GLANDS
HAMSTERS
MAMMALS
METABOLISM
NEOPLASMS
ORAL ADMINISTRATION
ORGANS
PATHOGENESIS
PROGRESS REPORT
RODENTS
VERTEBRATES