Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees

Journal Article · Mon Feb 01 04:00:00 EST 1993 · American Journal of Human Genetics; (United States)

OSTI ID:6831059

Coon, H; Byerley, W; Holik, J; Hoff, M; Myles-Worsley, M; Plaetke, R ^[1]; Lannfelt, L ^[2]; Sokoloff, P; Schwartz, J C ^[3]; Waldo, M; Freedman, R ^[4]

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1. Univ. of Utah, Salt Lake City (United States)
2. Karolinska Inst., Stockholm (Sweden)
3. Unite de Neurobiologie et de Pharmacologie de l'INSERM, Paris (France)
4. Univ. of Colorado, Denver (United States)

Alterations in dopamine neurotransmission have been strongly implicated in the pathogenesis of schizophrenia for nearly 2 decades. Recently, the genes for five dopamine receptors have been cloned and characterized, and genetic and physical map information has become available. Using these five loci as candidate genes, the authors have tested for genetic linkage to schizophrenia in nine multigenerational families which include multiple affected individuals. In addition to testing conservative disease models, the have used a neurophysiological indicator variable, the P50 auditory evoked response. Deficits in gating of the P50 response have been shown to segregate with schizophrenia in this sample and may identify carriers of gene(s) predisposing for schizophrenia. Linkage results were consistently negative, indicating that a defect at any of the actual receptor sites is unlikely to be a major contributor to schizophrenia in the nine families studied. 47 refs., 1 fig., 4 tabs.

• OSTI ID: 6831059
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 52:2; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL INDICATORS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DOPAMINE
DRUGS
GENE MUTATIONS
GENETIC MAPPING
HUMAN POPULATIONS
HYDROXY COMPOUNDS
MAPPING
MAPS
MEMBRANE PROTEINS
MENTAL DISORDERS
MUTATIONS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
POPULATIONS
PROTEINS
RECEPTORS
SYMPATHOMIMETICS