Genetic linkage analysis of schizophrenia using chromosome 11q13-24 markers in Israeli pedigrees

Journal Article · Mon Apr 24 04:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600204· OSTI ID:393890

Mulcrone, J; Marchblanks, R; Whatley, S A ^[1]

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1. Institute of Psychiatry, London (United Kingdom); and others

It is generally agreed that there is a genetic component in the etiology of schizophrenia which may be tested by the application of linkage analysis to multiply-affected families. One genetic region of interest is the long arm of chromosome 11 because of previously reported associations of genetic variation in this region with schizophrenia, and because of the fact that it contains the locus for the dopamine D2 receptor gene. In this study we have examined the segregation of schizophrenia with microsatellite dinucleotide repeat DNA markers along chromosome 11q in 5 Israeli families multiply-affected for schizophrenia. The hypothesis of linkage under genetic homogeneity of causation was tested under a number of genetic models. Linkage analysis provided no evidence for significant causal mutations within the region bounded by INT and D11S420 on chromosome 11q. It is still possible, however, that a gene of major effect exists in this region, either with low penetrance or with heterogeneity. 32 refs., 2 figs., 4 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 393890
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 2 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
DOPAMINE
ETIOLOGY
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOMES
ISRAEL
M CODES
MENTAL DISORDERS
NUCLEOTIDES
PATIENTS
RECEPTORS
S CODES
STATISTICAL MODELS