Acute inhalation toxicity of 3-methylfuran in the mouse: pathology, cell kinetics, and respiratory rate effects
The acute inhalation toxicity of 3-methylfuran (3MF) was investigated in male BALB/c mice by morphologic examination of animals killed at varying timepoints following a 1-hr exposure to an initial chamber concentration of 14 to 37 mumol/liter (343 to 906 ppm). In addition, respiratory rate measurements and cell kinetics were used to assess quantitatively pulmonary damage and repair. Necrosis of nonciliated bronchiolar epithelial (Clara) cells was seen 1 day following exposure and was followed by regeneration, which was virtually complete, within 21 days. Cell kinetic studies showed peak bronchiolar cell proliferation at 3 days with a labeling index (LI) of 5.0% compared to 0.4% in controls. An increase in parenchymal cell proliferation was also noted coincident with a mild interstitial pneumonitis. This parenchymal proliferation, peaking at 10 days with an LI of 1.4% compared to 0.2% in controls, consisted primarily of type II epithelial and endothelial cell proliferation indicating possible delayed damage and repair of type I epithelial and endothelial cells. The respiratory rate showed an initial transient increase followed by a more prolonged decrease with eventual return to control levels. 3MF toxicity was also evidenced by a necrotizing suppurative rhinitis, centrilobular hepatic necrosis, lymphocyte necrosis in the thymus and spleen, sialoadenitis, and otitis media.
- Research Organization:
- Biology Division, Oak Ridge National Laboratory, Tennessee
- OSTI ID:
- 6830064
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 72:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster
Pulmonary toxicity of methylcyclopentadienyl manganese tricarbonyl: nonciliated bronchiolar epithelial (Clara) cell necrosis and alveolar damage in the mouse, rat, and hamster
Related Subjects
FURANS
ACUTE EXPOSURE
BIOLOGICAL EFFECTS
INHALATION
RESPIRATORY TRACT CELLS
BIOLOGICAL REPAIR
CELL PROLIFERATION
BRONCHI
DYNAMIC FUNCTION STUDIES
LUNGS
MICE
PNEUMONITIS
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BODY
HETEROCYCLIC COMPOUNDS
INTAKE
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RECOVERY
REPAIR
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)