Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster
The acute inhalation toxicity of 3-methylfuran (3MF) was investigated in SPF Fischer-derived and CD/CR rats, and golden Syrian hamsters by determination of the 2-week LC/sub 50/, and by histologic examination of animals killed 1, 3, and 14 days following a 1-hr exposure to 148 and 322 ..mu..mole 3MF/liter for CD/CR rats and hamsters, respectively. The Fischer-derived rat was more sensitive to 3MF-induced lethality than the CD/CR rat with an LC/sub 50/ in the male rat of 81 ..mu..mole/liter-1 hr as compared to 222 ..mu..mole/liter-1hr. No sex difference was found. The hamster was relatively resistant with no lethality at 322 ..mu..mole 3MF/liter-2 hr. Pulmonary damage was present in both species. In the hamster, selective necrosis of nonciliated bronchiolar epithelial (Clara) cells was seen at 1 day with virtually complete regeneration by 14 days whereas in the rat the bronchiolar epithelial damage was more extensive and was followed by scattered peribronchiolar fibrosis and epithelial mucous metaplasia suggestive of ''small airway disease'' of man. Relatively selective 3MF-induced necrosis of olfactory epithelium occurred in the nasal mucosa of both species. Resolution of this lesion was seen by 14 days in the hamster. In the rat, however, the necrosis was much more extensive and was followed by partially occlusive fibrosis of the nasal cavity as seen at 14 days. 3MF also induced centrilobular hepatic necrosis in both species. In the rat, lymphocyte necrosis in the thymus and spleen, and esophageal necrosis was also seen.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6208383
- Journal Information:
- Exp. Mol. Pathol.; (United States), Vol. 39
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FURANS
TOXICITY
ANIMAL CELLS
BRONCHI
COMPARATIVE EVALUATIONS
EPITHELIUM
ESOPHAGUS
FIBROSIS
HAMSTERS
INHALATION
LIVER
LYMPHOCYTES
NECROSIS
PATHOLOGICAL CHANGES
PHARYNX
RATS
SENSITIVITY
SPLEEN
THYMUS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
GLANDS
HETEROCYCLIC COMPOUNDS
INTAKE
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)