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Title: Effects of zinc-deficient diets on the cardiovascular system in rabbits

Abstract

The authors used male New Zealand white rabbits to study the effects of zinc-deficient diets on the cardiovascular system. These 10 week-old rabbits were fed semi-purified diets containing either 50 ppm or less than 1 ppm zinc for 12 weeks. Serum samples were analyzed at 3,6,9 and 12 weeks. Body weight and food consumption were measured weekly. At necropsy the liver and heart were removed and weighed. Then the heart was perfused at 100 mm Hg with 10% buffered formalin via the ascending aorta. Coronary arteries were block-dissected and processed for light microscopy. Food consumption and body weights were not significantly altered throughout the study. Relative heart weights were not different; however, the relative liver weight of the zinc-deficient group was elevated by 11%. Neither total serum cholesterol or HDL-cholesterol were changed at any time. After 6 weeks treatment, serum zinc levels were depressed by 29% in the zinc-deficient group; no changes were observed for serum copper or calcium. Morphometric analysis of coronary arteries revealed a decreased combined thickness of the tunica intima and tunica media and a decreased area per unit length in the left coronary circumflex arteries of zinc-deficient rabbits. Significant changes reported here are probably related tomore » possible alterations in lipoproteins metabolism and will be investigated in future studies.« less

Authors:
;
Publication Date:
Research Org.:
Oral Roberts Univ., Tulsa, OK
OSTI Identifier:
6829236
Alternate Identifier(s):
OSTI ID: 6829236
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA
Resource Type:
Journal Article
Journal Name:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
Additional Journal Information:
Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARDIOVASCULAR DISEASES; PATHOGENESIS; CORONARIES; PATHOLOGICAL CHANGES; ZINC; BIOLOGICAL EFFECTS; NUTRITIONAL DEFICIENCY; CHOLESTEROL; DIET; HEART; LIVER; PERFUSED ORGANS; RABBITS; ANIMALS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DIGESTIVE SYSTEM; DISEASES; ELEMENTS; GLANDS; HYDROXY COMPOUNDS; MAMMALS; METALS; ORGANIC COMPOUNDS; ORGANS; STEROIDS; STEROLS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Carter, J.W., and Koo, S.I. Effects of zinc-deficient diets on the cardiovascular system in rabbits. United States: N. p., 1986. Web.
Carter, J.W., & Koo, S.I. Effects of zinc-deficient diets on the cardiovascular system in rabbits. United States.
Carter, J.W., and Koo, S.I. Wed . "Effects of zinc-deficient diets on the cardiovascular system in rabbits". United States.
@article{osti_6829236,
title = {Effects of zinc-deficient diets on the cardiovascular system in rabbits},
author = {Carter, J.W. and Koo, S.I.},
abstractNote = {The authors used male New Zealand white rabbits to study the effects of zinc-deficient diets on the cardiovascular system. These 10 week-old rabbits were fed semi-purified diets containing either 50 ppm or less than 1 ppm zinc for 12 weeks. Serum samples were analyzed at 3,6,9 and 12 weeks. Body weight and food consumption were measured weekly. At necropsy the liver and heart were removed and weighed. Then the heart was perfused at 100 mm Hg with 10% buffered formalin via the ascending aorta. Coronary arteries were block-dissected and processed for light microscopy. Food consumption and body weights were not significantly altered throughout the study. Relative heart weights were not different; however, the relative liver weight of the zinc-deficient group was elevated by 11%. Neither total serum cholesterol or HDL-cholesterol were changed at any time. After 6 weeks treatment, serum zinc levels were depressed by 29% in the zinc-deficient group; no changes were observed for serum copper or calcium. Morphometric analysis of coronary arteries revealed a decreased combined thickness of the tunica intima and tunica media and a decreased area per unit length in the left coronary circumflex arteries of zinc-deficient rabbits. Significant changes reported here are probably related to possible alterations in lipoproteins metabolism and will be investigated in future studies.},
doi = {},
journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:4,
place = {United States},
year = {1986},
month = {3}
}