Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Journal of Clinical Endocrinology and Metabolism; (United States)

DOI:https://doi.org/10.1210/jcem.76.1.8421078· OSTI ID:6827940

Falchetti, A; Brandi, M L ^[1]; Amorosi, A; Cicchi, P; Bandini, S ^[2]; Bordi, C ^[3]; Marx, S J ^[4]

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1. Univ. of Florence (Italy) Yale Univ. School of Medicine, New Haven, CT (United States)
2. Univ. of Florence (Italy)
3. Univ. of Parma (Italy)
4. National Institute of Health, Bethesda, MD (United States)

In occasional cases of secondary hyperparathyroidism, long term stimulation of the parathyroid glands leads from compensatory to autonomous hyperfunction, and thus, hypercalcemia develops. This clinical entity, named tertiary hyperparathyroidism, is possibly due to the formation of an adenoma in one of the hyperplastic glands. Previous studies have shown that parathyroid adenomas may arise with allelic loss on chromosome 11. The authors tested for allelic loss at several loci on chromosome 11 in 12 enlarged parathyroid glands from 6 uremic patients and found loss of heterozygosity in 2 of the glands from 2 different patients with higher serum calcium levels (11.3 [+-] 0.29 vs. 9.8 [+-] 0.28 mg/dL; P < 0.004) and, therefore, ascribable to the so-called tertiary hyperparathyroidism. The 2 glands with allelic loss were significantly greater in mass than those without loss (3.42 [+-] 0.37 vs. 1.60 [+-] 0.54 g; P < 0.001). These data offer new evidence that autonomous parathyroid proliferation in uremic patients can develop through over-growth by a monoclonal tumor, presumably with inactivation of a tumor suppressor gene(s) on chromosome 11. 33 refs., 4 figs., 2 tabs.

• OSTI ID: 6827940
• Journal Information: Journal of Clinical Endocrinology and Metabolism; (United States), Journal Name: Journal of Clinical Endocrinology and Metabolism; (United States) Vol. 76:1; ISSN JCEMAZ; ISSN 0021-972X
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ADENOMAS
ALKALINE EARTH METALS
BODY
CALCIUM
CARCINOMAS
CHROMOSOMES
DISEASES
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GENE MUTATIONS
GLANDS
HUMAN CHROMOSOMES
HYPERPARATHYROIDISM
METABOLIC DISEASES
METALS
MUTATIONS
NEOPLASMS
ORGANS
PARATHYROID GLANDS