Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Hyperparathyroidism after radioactive iodine therapy for Graves disease

Journal Article · · Surgery; (United States)
OSTI ID:6622144
; ; ; ;
The association of external ionizing radiation to the head and neck and the subsequent development of hyperfunctioning parathyroid glands has been documented in recent years. This also has been demonstrated experimentally in animals. Despite the numbers of patients with Graves disease who have been treated with radioactive iodine, there are no reports in the literature of parathyroid surgery for hyperparathyroidism secondary to earlier treatment with radioactive iodine for Graves disease. This report describes the operative and pathologic findings in four patients with hyperparathyroidism. These patients had previously been treated with radioactive iodine for Graves disease. The pathologic findings at surgery included in three cases a single enlarged hyperplastic gland consistent with a parathyroid adenoma. One patient had hyperplasia of all four glands. The two largest glands and halves of the two remaining glands were removed. In a long-term follow-up of children and adolescents treated with radioactive iodine for Graves disease, Levy and Schumacher found calcium elevations in 10 of 159 patients. The increased incidence of hyperparathyroidism following radioactive iodine treatment for Graves disease in children and adolescents would seem several times higher than normal. Whether adults who have radioactive iodine treatment for Graves disease have a similar increase incidence is not known. Meanwhile it would seem reasonable to suggest that patients whose hyperthyroidism is treated with radioactive iodine should have their serum calcium levels determined at 5-year intervals.
Research Organization:
Cleveland Clinic Foundation, Ohio
OSTI ID:
6622144
Journal Information:
Surgery; (United States), Journal Name: Surgery; (United States) Vol. 92:5; ISSN SURGA
Country of Publication:
United States
Language:
English

Similar Records

Hyperparathyroidism After Irradiation for Childhood Malignancy
Journal Article · Sun Mar 15 00:00:00 EDT 2009 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:21172680
Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11
Journal Article · Thu Dec 31 23:00:00 EST 1992 · Journal of Clinical Endocrinology and Metabolism; (United States) · OSTI ID:6827940
Enhanced thyroid iodine metabolism in patients with triiodothyronine-predominant Graves' disease
Journal Article · Thu Dec 31 23:00:00 EST 1987 · J. Clin. Endocrinol. Metab.; (United States) · OSTI ID:5595285

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
GOITER
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOTOPES
LOCAL IRRADIATION
MEDICINE
NECK
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARATHYROID GLANDS
PATIENTS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY