Hyperparathyroidism after radioactive iodine therapy for Graves disease
The association of external ionizing radiation to the head and neck and the subsequent development of hyperfunctioning parathyroid glands has been documented in recent years. This also has been demonstrated experimentally in animals. Despite the numbers of patients with Graves disease who have been treated with radioactive iodine, there are no reports in the literature of parathyroid surgery for hyperparathyroidism secondary to earlier treatment with radioactive iodine for Graves disease. This report describes the operative and pathologic findings in four patients with hyperparathyroidism. These patients had previously been treated with radioactive iodine for Graves disease. The pathologic findings at surgery included in three cases a single enlarged hyperplastic gland consistent with a parathyroid adenoma. One patient had hyperplasia of all four glands. The two largest glands and halves of the two remaining glands were removed. In a long-term follow-up of children and adolescents treated with radioactive iodine for Graves disease, Levy and Schumacher found calcium elevations in 10 of 159 patients. The increased incidence of hyperparathyroidism following radioactive iodine treatment for Graves disease in children and adolescents would seem several times higher than normal. Whether adults who have radioactive iodine treatment for Graves disease have a similar increase incidence is not known. Meanwhile it would seem reasonable to suggest that patients whose hyperthyroidism is treated with radioactive iodine should have their serum calcium levels determined at 5-year intervals.
- Research Organization:
- Cleveland Clinic Foundation, Ohio
- OSTI ID:
- 6622144
- Journal Information:
- Surgery; (United States), Journal Name: Surgery; (United States) Vol. 92:5; ISSN SURGA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11
Enhanced thyroid iodine metabolism in patients with triiodothyronine-predominant Graves' disease
Related Subjects
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
GOITER
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOTOPES
LOCAL IRRADIATION
MEDICINE
NECK
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARATHYROID GLANDS
PATIENTS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY