Dose-response analysis of ingested benzo(a)pyrene (CAS No. 50-32-8)

Technical Report · Sun Dec 01 04:00:00 EST 1991

OSTI ID:6823278

Chen, C W; Chu, M M.L.

The report represents the first part of the Office of Health and Environmental Assessment's dose-response analysis of polycyclic aromatic hydrocarbons (PAHs). Because of the tremendous amount of information bearing on approaches that can be developed to estimate risks from exposures to PAHs, the task is divided into three steps beginning with an analysis of benzo(a)pyrene (BAP), one of the PAHs. The steps are: (1) determining the oral potency slope for benzo(a)pyrene (B(a)P), (2) determining the inhalation potency slope for B(a)P, and (3) determining the potency slopes for other PAHs using a relative potency approach. The focus of the report is on estimating the carcinogenic potency slope of B(a)P by ingestion. The potency slope is used to provide an upper-bound estimate for risk from ingesting low doses of B(a)P. It should be noted that only information relevant to analyzing dose-response relationships by ingestion is analyzed in the report.

• Research Organization: Environmental Protection Agency, Washington, DC (United States). Office of Health and Environmental Assessment
• OSTI ID: 6823278
• Report Number(s): PB-93-167484/XAB; EPA--600/R-92/045
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZOPYRENE
BIOCHEMISTRY
BIOLOGY
CARCINOGENS
CHEMISTRY
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVALUATION
FORECASTING
HYDROCARBONS
INFORMATION NEEDS
INGESTION
INHALATION
INTAKE
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
PUBLIC HEALTH
RISK ASSESSMENT