Carbohydrate composition of immunoglobulins from diverse species of verterbrates

Journal Article · Tue Aug 01 04:00:00 EDT 1972 · J. Immunol.; (United States)

OSTI ID:6819955

Acton, R T; Niedermeier, W; Weinheimer, P F; Clem, L W; Leslie, G A; Bennett, J C

Immunoglobulins and their respective heavy (H) and light (L) polypeptide chains from species representing the major classes of vertebrates were analyzed for their carbohydrate composition by gas chromatography of the alditol acetate derivatives of the monosaccharides released by acid hydrolysis. Mannose, galactose, glucosamine and sialic acid were present in the immunoglobulins from all the species investigated. Most of the carbohydrate was found associated with the H chains. Whereas species representative of the mammals and birds had mannose to galactose ratios greater than one, the ratio to these sugars to each other in the immunoglobulins from animals below the birds was on the order of one.

• Research Organization: California Inst. of Technology, Pasadena
• OSTI ID: 6819955
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 109:2; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
AMINES
AMPHIBIANS
ANIMALS
AQUATIC ORGANISMS
BIRDS
CARBOHYDRATES
CHEMICAL COMPOSITION
CHICKENS
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
DUCKS
FISHES
FOWL
GALACTOSE
GAS CHROMATOGRAPHY
GLOBULINS
GLUCOSAMINE
HEXOSAMINES
HEXOSES
IMMUNOGLOBULINS
MAMMALS
MAN
MANNOSE
MONOSACCHARIDES
ORGANIC COMPOUNDS
POLYSACCHARIDES
PRIMATES
PROTEINS
REPTILES
SACCHARIDES
SEPARATION PROCESSES
SIALIC ACID
TOADS
TURTLES
VERTEBRATES