Immunosuppression and reconstitution with thymosin after radiation therapy
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6818725
Since 1976, 102 patients with advanced squamous cell carcinoma, (82, head and neck; 20, esophagus), have been evaluated before receiving irradiation and thymosin fraction 5 therapy at the University of California, San Francisco (UCSF). Thymosin fraction 5 is a mixture of at least 20 polypeptides which has been shown to have immune enhancing capabilities in primary immunodeficiency disease and various malignancies. Immunity prior to treatment (measured by total lymphocyte count, E and EAC rosettes, lymphocyte stimulation with phytohemagglutinin (PHA) and in mixed leukocyte culture (MLC) with allogeneic cells and quantitative serum immunoglobulins) was comparable and normal in the 80 control patients and the 22 thymosin treated patients. Postirradiation significant depression (p<0.01) was demonstrated in cellular immunity in both groups of patients with decreased T and B cell numbers and depressed PHA and MLC stimulation. To date there have been an equal number of recurrences and deaths in both groups of patients.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6818725
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CARCINOMAS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
HEAD
HORMONES
IMMUNE REACTIONS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
THYMUS
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CARCINOMAS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
HEAD
HORMONES
IMMUNE REACTIONS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
THYMUS