Survival of intestinal crypt cells after exposure to high Z, high-energy charged particles

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575347· OSTI ID:6817993

Alpen, E L; Powers-Risius, P; McDonald, M

The Withers intestinal crypt clonogenic cell assay has been used to assess the relative effectiveness of high-energy heavy ions for cell killing in this system. The radiation modalities used are 228 MeV/amu helium ions and 400 to 670 meV/amu carbon, neon, and argon ions. These high-LET particle beams have been examined and their effect on both the shoulder of the cell survival curve and the region of exponential cell killing has been examined. All ions except helium are significantly more effective than 225-kVp x rays. There is both an effect on the shoulder, evidenced in a narrowing of this region, and an effect on the exponential region where the D/sub 0/ is reduced. This latter finding is in sharp distinction to the effects of neutron beams, where the shoulder is reduced, but the D/sub 0/ is unaffected. One of the most significant observations made in these studies is that LET alone does not predict the effectiveness of the various ions. Large differences in effectiveness are seen as a function of atomic number of the particle, even though the LET is held approximately constant.

• Research Organization: Univ. of California, Berkeley
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6817993
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560151 -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARGON 40 BEAMS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BRAGG CURVE
CARBON 12 BEAMS
CELL KILLING
CHARGED PARTICLES
COMPARATIVE EVALUATIONS
CRYPT CELLS
DATA
DEPTH DOSE DISTRIBUTIONS
DIAGRAMS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENERGY RANGE
ENERGY TRANSFER
EXPERIMENTAL DATA
FLUIDS
GASES
HEAVY IONS
HELIUM
INFORMATION
ION BEAMS
IONIZING RADIATIONS
IONS
LET
MAMMALS
MEV RANGE
MEV RANGE 100-1000
MICE
NEON 20 BEAMS
NEUTRON BEAMS
NONMETALS
NUCLEON BEAMS
NUMERICAL DATA
PARTICLE BEAMS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIATIONS
RARE GASES
RBE
RODENTS
SOMATIC CELLS
SPATIAL DOSE DISTRIBUTIONS
SURVIVAL CURVES
VERTEBRATES
X RADIATION