Carcinogenicity and mutagenicity of benz(a)anthracene iols and diol-epoxides

Journal Article · Thu Jun 01 04:00:00 EDT 1978 · Cancer Res.; (United States)

OSTI ID:6817843

Slaga, T J; Huberman, E; Selkirk, J K; Harvey, R G; Bracken, W M

Benz(a)anthracene (BA) and its five possible trans-dihydrodiols were evaluated for determination of their skin tumor-initiating activity and their mutagenic activity in Chinese hamster V79 cells. In addition, the skin tumor-initiating abilities of five diol-epoxides of BA were tested. Results showed (+-)-trans-3,4-dihydroxy-3,4-dihydrobenz(a)anthracene (BA 3,4-dihydrodiol) to be approximately 10 times more mutagenic than was BA and about 20 times more mutagenic than were the other possible dihydrodiols in the V79 cells cocultivated with irradiated hamster embryo cells. As a skin tumor initiator, BA 3,4-dihydrodiol was approximately 5 times more active than BA, whereas the other BA dihydrodiols were all less active tumor initiators. (+-)-trans-3..cap alpha..,4..beta..-Dihydroxy-1..cap alpha..,2..cap alpha..-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene was found to be approximately 20% more active as a tumor initiator than was BA 3,4-dihydrodiol, whereas the other diol-epoxides of BA were less active than BA itself. The results suggest that the bay-region diol-epoxide of BA may be the ultimate carcinogenic and mutagenic form of BA.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 6817843
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38:6; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
ANIMAL CELLS
ANIMALS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DISEASES
GLYCOLS
HAMSTERS
HYDROXY COMPOUNDS
MAMMALS
MUTAGENESIS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SKIN
VERTEBRATES