Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein

Journal Article · Fri Aug 01 00:00:00 EDT 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90150-4· OSTI ID:6816832

Fullmer, C S; Oku, T; Wasserman, R H

The effects of cadmium on intestinal calcium absorption and calcium-binding protein (CaBP) were investigated in chicks by means of the in situ ligated duodenal loop technique. Dietary cadmium, administered in the feed or by gastric intubation, resulted in significant declines in intestinal calcium absorption and mucosal calcium-binding protein concentrations. Cadmium chloride injected directly into the ligated loop of naive chicks also diminished calcium absorption and CaBP concentrations in an apparently dose-response related fashion. No adverse effects of cadmium administration on either the 25- or 1..cap alpha..-hydroxylation reactions of vitamin D were observed. While the general effect of cadmium administration was a reduction in intestinal calcium absorption, plasma calcium levels were consistently elevated in Cd-treated chicks, with the exception of those also maintained on diets low in Ca. The results indicate that cadmium toxicity exerts at least two effects on Ca metabolism, one at the intestinal level and another at the level of the bone, kidney, or both.

• Research Organization: Cornell Univ., Ithaca, NY
• OSTI ID: 6816832
• Journal Information: Environ. Res.; (United States), Vol. 22:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL EFFECTS
CALCIUM
INTESTINAL ABSORPTION
CHICKENS
EXPERIMENTAL DATA
INFANTS
INGESTION
PROTEINS
QUANTITY RATIO
TOXICITY
VITAMIN D
ABSORPTION
AGE GROUPS
ALKALINE EARTH METALS
ANIMALS
BIRDS
CHILDREN
DATA
ELEMENTS
FOWL
INFORMATION
INTAKE
MAMMALS
MAN
METALS
NEONATES
NUMERICAL DATA
ORGANIC COMPOUNDS
PRIMATES
UPTAKE
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)