Positron emission tomographic imaging of the myocardium with /sup 81/Rb

Journal Article · Thu Apr 01 04:00:00 EST 1982 · J. Comput. Assist. Tomogr.; (United States)

DOI:https://doi.org/10.1097/00004728-198204000-00020· OSTI ID:6816680

Beller, G A; Cochavi, S; Smith, T W; Brownell, G L

An approach to the assessment of regional myocardial perfusion has been developed utilizing positron emission tomographic imaging of the heart after intravenous administration of /sup 81/Rb (T1/2.4.6 hr) and a multicrystal positron camera. In five intact anesthetized dogs, 1.0 to 2.0 mCi of /sup 81/ RbCl was administered and imaging begun 5 min later. A total of 7 to 9 transverse section images of the heart (1 cm thick) were obtained by the computer reconstruction of 208 images taken at uniformly spaced angles as the camera was rotated 180 degrees around the animal. Collection time was 18 min. Emission images of /sup 81/Rb activity were corrected for attenuation by first obtaining transmission data using a planar positron-emitting source. Transverse section images through the apex of the heart showed uniform uptake of /sup 81/Rb+ activity below the left ventricular (LV) cavity. Tomographic images through the midventricular level showed myocardial /sup 81/Rb+ distribution in an annular pattern around the LV cavity, and tomographic cuts through the base of the heart showed a horseshoe appearance of activity anteriorly and diminished tracer uptake posteriorly in the region of the left atrial wall. These studies demonstrate the feasibility of three-dimensional myocardial imaging by using the 33% positron emission of /sup 81/Rb+ and a positron camera.

• Research Organization: Department of Medicine and Physics Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts
• OSTI ID: 6816680
• Journal Information: J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 6:2; ISSN JCATD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUBIDIUM 81
RUBIDIUM ISOTOPES
SCINTISCANNING
TOMOGRAPHY
USES
VERTEBRATES