Evaluation of biological indicators of body burden of cadmium in humans

Journal Article · · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/S0272-0590(83)80077-3· OSTI ID:6815244

Ellis, K J; Yasumura, S; Vartsky, D; Cohn, S H

The cadmium content in the left kidney (KCd) and concentration in the liver (LCd) were measured in vivo in 51 adult male workers actively employed at a cadmium plant and in 10 nonexposed controls. Cadmium levels in blood (BCd), urine (UCd) and hair (HCd) were also obtained for each subject. When the workers were classified on the basis of urinary excretion of ..beta../sub 2/-microglobulin, albumin and total protein, 33 workers were judged to have normal renal function, and 18 workers were found to have renal dysfunction. In the two groups of industrial workers the mean value for each biological index of cadmium exposure was statistically elevated when compared with the mean value for the controls. Examination of the interrelationships among KCd, LCd, BCd, UCd and HCd provided the following conclusions: (a) Only on a group basis was UCd correlated (r = 0.61) with KCd in workers with normal renal function; (b) BCd was corrected with LCd in workers with normal kidney function (r = 0.53) and in workers with renal dysfunction (r = 0.68); (c) HCd had the largest variability of the biological indices and was unrelated to body burden; (d) KCd and LCd were positivley correlated in workers with normal kidney function, whereas KCd decreased with increasing LCd in workers with renal dysfunction. This study demonstrates that the qualitative nature of the relationship of BCd, UCd and HCd (biological indices of exposure) with KCd and LCd (body burden) is not sufficiently quantitative for predicting the body burden of an individual worker.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6815244
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 3:5-6; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY BURDEN
BODY FLUIDS
CADMIUM
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
ELEMENTS
FUNCTIONS
GLANDS
HAIR
IN VIVO
KIDNEYS
LIVER
MALES
MAMMALS
MAN
MATERIALS
MEASURING METHODS
MEN
METALS
ORGANIC COMPOUNDS
ORGANS
POLLUTION
PRIMATES
PROTEINS
SKIN
URINE
VERTEBRATES
WASTES