Pressure and composition gradients in capillary supercritical fluid chromatography

Journal Article · Sun Mar 01 04:00:00 EST 1987 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00132a010· OSTI ID:6813678

Yonker, C R; Smith, R D

Initial studies on the effects of fluid modifier gradients and fluid modifier-pressure gradients on solute retention in capillary supercritical fluid chromatography have been examined. The introduction of a solvent modifier has two effects: (1) a change in the density of the mobile phase and (2) modification of the type of solute-solvent interaction. The addition of a fluid modifier results in substantial changes in density which can be readily calculated. The resulting changes in intermolecular interactions between the solute-binary fluid mobile phase on solute selectivity and retention are discussed. Modifier gradients and modifier-pressure gradients are shown to yield decreased analysis times when compared to pure fluid solvents, while maintaining adequate resolution between components of a homologous series of n-alkylphenones.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6813678
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 59:5; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400105* -- Separation Procedures
ADDITIVES
AROMATICS
BLOOD VESSELS
BODY
CAPILLARIES
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CHEMICAL ANALYSIS
CHEMICAL COMPOSITION
CHROMATOGRAPHY
DATA
DENSITY
EFFICIENCY
EXPERIMENTAL DATA
INFORMATION
KETONES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHASE STUDIES
PHYSICAL PROPERTIES
PRESSURE DEPENDENCE
PRESSURE GRADIENTS
QUANTITATIVE CHEMICAL ANALYSIS
RESOLUTION
SEPARATION PROCESSES
SOLUTES
SOLVENTS
SUPERCRITICAL FLUID CHROMATOGRAPHY