Thallium-201 scintigraphy in bone sarcoma: Comparison with gallium-67 and technetium-MDP in the evaluation of chemotherapeutic response

Journal Article · Tue May 01 04:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6809512

Ramanna, L; Waxman, A; Binney, G; Waxman, S; Mirra, J; Rosen, G ^[1]

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1. Cedars-Sinai Medical Center, Los Angeles, CA (USA)

This study attempts to characterize thallium-201 ({sup 201}TI) uptake in patients with bone and soft-tissue sarcoma and to compare these findings with gallium-67 ({sup 67}Ga) and bone scintigraphy with emphasis on evaluating tumor viability before and after chemotherapy. Thirty-eight patients with surgically-proven sarcomas were evaluated. All patients had gallium and thallium studies. Nineteen patients underwent pre- and post-chemotherapy thallium and evaluation. Seven patients also had technetium-99m-MDP ({sup 99m}Tc-MDP) bone scintigraphy comparisons. Pathologic changes pre- and postchemotherapy were graded on the basis of %tumor necrosis as defined histologically. Scintigraphic comparisons demonstrated a high degree of correlation with {sup 201}TI and poor correlation with {sup 99m}Tc-MDP. Thallium-201 was superior to {sup 99m}Tc-MDP and {sup 67}Ga in predicting tumor response to chemotherapy as determined by %tumor necrosis determined histologically. Gallium was superior to Tc-MDP in predicting response to chemotherapy. However, both {sup 67}Ga and {sup 99m}Tc-MDP appear to be affected by factors other than tumor activity.

• OSTI ID: 6809512
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:5; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
CHEMOTHERAPY
CITRATES
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SARCOMAS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES