A feasibility study of [sup 252]Cf neutron brachytherapy, cisplatin + 5-FU chemo-adjuvant and accelerated hyperfractionated radiotherapy for advanced cervical cancer

Journal Article · Wed Jun 15 04:00:00 EDT 1994 · International Journal of Radiation Oncology, Biology and Physics; (United States)

DOI:https://doi.org/10.1016/0360-3016(94)90450-2· OSTI ID:6809455

Murayama, Y; Wierzbicki, J ^[1]; Bowen, M G; Van Nagell, J R; Gallion, H H; DePriest, P ^[2]

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1. Wayne State Univ., Detroit, MI (United States) Univ. of Kentucky Medical Center, Lexington, KY (United States)
2. Univ. of Kentucky Medical Center, Lexington, KY (United States)

The purpose was to evaluate the feasibility and toxicity of [sup 252]Cf neutron brachytherapy combined with hyperaccelerated chemoradiotherapy for Stage III and IV cervical cancers. Eleven patients with advanced Stage IIIB-IVA cervical cancers were treated with [sup 252]Cf neutron brachytherapy in an up-front schedule followed by cisplatin (CDDP; 50 mg/m[sup 2]) chemotherapy and hyperfractionated accelerated (1.2 Gy bid) radiotherapy given concurrently with intravenous infusion of 5-Fluorouracil (5-FU) (1000 mg/m[sup 2]/day [times] 4 days) in weeks 1 and 4 with conventional radiation (weeks 2, 3, 5, and 6). Total dose at a paracervical point A isodose surface was 80-85 Gy-eq by external and intracavitary therapy and 60 Gy at the pelvic sidewalls. Patients tolerated the protocol well. There was 91% compliance with the chemotherapy and full compliance with the [sup 252]Cf brachytherapy and the external beam radiotherapy. There were no problems with acute chemo or radiation toxicity. One patient developed a rectovaginal fistula (Grade 3-4 RTOG criteria) but no other patients developed significant late cystitis, proctitis or enteritis. There was complete response (CR) observed in all cases. With mean follow-up to 26 months, local control has been achieved with 90% actuarial 3-year survival with no evidence of disease (NED). [sup 252]Cf neutrons can be combined with cisplatin and 5-FU infusion chemotherapy plus hyperaccelerated chemoradiotherapy without unusual side effects or toxicity and with a high local response and tumor control rate. Further study of [sup 252]Cf neutron-chemoradiotherapy for advanced and bulky cervical cancer are indicated. The authors found chemotherapy was more effective with the improved local tumor control. 18 refs., 2 tabs.

• OSTI ID: 6809455
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (United States), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (United States) Vol. 29:3; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANTIMETABOLITES
AZINES
BEAMS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
DISEASES
DRUGS
EVEN-EVEN NUCLEI
FEMALE GENITALS
FLUOROURACILS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPES
MEDICINE
NEOPLASMS
NEUTRON BEAMS
NUCLEAR MEDICINE
NUCLEI
NUCLEON BEAMS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTICLE BEAMS
PLATINUM COMPOUNDS
PYRIMIDINES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SPONTANEOUS FISSION RADIOISOTOPES
SYNERGISM
THERAPY
TRANSITION ELEMENT COMPOUNDS
URACILS
UTERUS
YEARS LIVING RADIOISOTOPES