Regeneration in cervix cancer after sup 252 Cf neutron brachytherapy

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90135-7· OSTI ID:6791456

Maruyama, Y; Wierzbicki, J; Feola, J; Urano, M ^[1]

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1. Univ. of Kentucky Medical Center, Lexington (USA)

Regeneration of clonogens in human cervical cancer was assessed by the pathological evaluation of the hysterectomy specimen after intracavitary {sup 252}Cf neutron brachytherapy implants separated by varying time intervals followed by extrafascial hysterectomy. In this study, patients with bulky/barrel shaped Stage IB cervical cancers received {sup 252}Cf implants plus approximately 45 Gy of whole pelvis linear accelerator radiotherapy in approximately 25 fractions in 5 weeks followed by hysterectomy 4-6 weeks after radiotherapy. The specimens were studied grossly and microscopically for residual tumor. It was found that the fraction of positive specimens increased with elapsed time interval between implants. These findings support the hypothesis that there is repopulation of surviving clonogens with increased time interval between the implants. The observation also supports current concerns that rapid depopulation of tumor can lead to rapid repopulation, that is, rapid shrinkage of tumor can alter the physiological environment such that clonogens can rapidly regenerate.

• OSTI ID: 6791456
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 19:1; ISSN IOBPD; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BARYONS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
DISEASES
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
FEMALE GENITALS
FERMIONS
FRACTIONATED IRRADIATION
HADRONS
HEAVY NUCLEI
IMPLANTS
IRRADIATION
ISOTOPES
MAMMALS
MAN
MEDICINE
NEOPLASMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ORGANS
PATIENTS
PRIMATES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECOVERY
THERAPY
UTERUS
VERTEBRATES
YEARS LIVING RADIOISOTOPES