Influence of risk area size and location on native collateral resistance and ischemic zone perfusion

Journal Article · Tue Mar 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6808862

Gumm, D C; Cooper, S M; Thompson, S B; Marcus, M L; Harrison, D C ^[1]

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1. Univ. of Iowa College of Medicine, Iowa City (USA)

To examine the effect of risk area size on collateral resistance and ichemic region perfusion, the authors produced different sized risk areas by occluding either the left anterior descending (LAD) or the circumflex (Cx) coronary artery at different sites. The most proximal occlusion of the LAD and Cx produced risk areas of 43 {plus minus} 5 and 36 {plus minus} 2% of left ventricular (LV) mass, respectively, whereas distal LAD and Cx occlusions produced risk areas of 13 {plus minus} 2 and 17 {plus minus} 2% of LV weight, respectively. Although total collateral flow was highest to the largest risk areas, collateral flow per 100 g of ischemic myocardium was 80% higher to the small LAD risk area compared with the large LAD risk area and 43% higher to the small Cx risk area compared with the large Cx risk area. Collateral resistance, calculated from the transcollateral pressure and perfusion per 100 g of myocardium was significantly lower in the small risk areas than in the large ones. They examined the effect of risk area location on collateral perfusion and resistance. These experiments show that collateral resistance is influenced both by ischemic region size and location. Small risk areas receive more collateral flow per mass of tissue than large risk areas, and apical risk areas receive greater quantities of collateral flow than those located at the base. These data may explain why small risk areas often do not develop infarction after coronary occlusion.

• OSTI ID: 6808862
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
CORONARIES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GADOLINIUM 153
GADOLINIUM ISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NIOBIUM 95
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PERFUSED TISSUES
PHYSIOLOGY
RADIOASSAY
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
STRONTIUM 85
STRONTIUM ISOTOPES
TIN 113
TIN ISOTOPES
TISSUES
VASCULAR DISEASES
VERTEBRATES