Quantitation of collateral and ischemic flows with microspheres and diffusible indicator

Journal Article · Sat Apr 01 04:00:00 EST 1978 · Am. J. Psychol.; (United States)

OSTI ID:5408973

Cohen, M V

Flow to myocardium following coronary occlusion may not originate solely from collateral channels. Some flow might be derived from overlapping coronary arteries which also perfuse tissue within the territory of the obstructed vessel prior to occlusion. Left atrial microsphere injection during perfusion of the left anterior descending (LAD) artery from a special reservoir containing microsphere-free blood and again after LAD occlusion permitted measurement of noncollateral overlap and total ischemic LAD (TIF) flows, respectively, and mathematical derivation of true collateral flow (TCF). Whereas TIF averaged 0.25 +/- 0.03 ml/min per g, TCF was 0.14 +/- 0.03 ml/min per g, only 50.6% of TIF. The remainder of the TIF represented either inadvertant myocardium or actual overlap of LAD and left circumflex circulations. 86 RbCl was injected simultaneously with the microspheres following coronary occlusion. 86 Rb and microsphere densities in the whole heart and ischemic area were closely correlated, although microsphere distribution tended to be more heterogeneous. No segment of ischemic myocardium containing 86 Rb was free of microspheres. Therefore, the geometry of undeveloped collateral channels is adequate to permit passage of 15-micron particles. Absolute 86 Rb flows were consistently less than microsphere flows.

• Research Organization: Montefiore Hospital and Medical Center, Bronx, NY
• OSTI ID: 5408973
• Journal Information: Am. J. Psychol.; (United States), Journal Name: Am. J. Psychol.; (United States) Vol. 234:4; ISSN AJPCA
• Country of Publication: United States
• Language: English

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551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ALKALI METALS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD FLOW
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
CORONARIES
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELEMENTS
HALIDES
HALOGEN COMPOUNDS
HEART
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEASURING METHODS
METALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGY
PHYSIOLOGY
RADIOISOTOPES
RUBIDIUM
RUBIDIUM 86
RUBIDIUM CHLORIDES
RUBIDIUM COMPOUNDS
RUBIDIUM ISOTOPES
VERTEBRATES