Photoreactivation in bacteria and in skin

Conference · Tue Jan 01 04:00:00 EST 1980

OSTI ID:6807984

Sutherland, B M

In many procaryotic and eucaryotic cells, photoreactivating enzyme mediates light-dependent repair of uv-induced damage; the enzyme binds to a pyrimidine dimer in DNA, and, on absorption of a photon (300 to 600 nm), specifically monomerizes the dimer, thus repairing the DNA. Photoreactivating enzyme has been found in human tissues and human cells in culture can photoreactivate cellular dimers, and can mediate photoreactivation of Herpes (human fibroblasts) and Epstein-Barr virus (human leukocytes). Measurements of pyrimidine dimer formation and repair in human skin indicate that detectable numbers of dimers are formed at 1 minimal erythemal dose, that the dimiers are rapidly removed in skin kept in the absence of light, and they are more rapidly removed when the skin is exposed to visible light. Whether this apparent photorecovery is true, enzymatic photoreactivation is yet to be determined.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6807984
• Report Number(s): BNL-28385; CONF-8010102-1
• Country of Publication: United States
• Language: English

Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AZINES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DIMERS
DNA
ELECTROMAGNETIC RADIATION
ENZYMES
HETEROCYCLIC COMPOUNDS
INJURIES
MAMMALS
MAN
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOTOREACTIVATION
PRIMATES
PYRIMIDINES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
SKIN
ULTRAVIOLET RADIATION
VERTEBRATES
VISIBLE RADIATION