Ethanol-nicotine interactions in long-sleep and short-sleep mice

Journal Article · Tue May 01 04:00:00 EDT 1990 · Alcohol; (USA)

DOI:https://doi.org/10.1016/0741-8329(90)90014-4· OSTI ID:6807912

de Fiebre, C M; Marks, M J; Collins, A C ^[1]

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1. Univ. of Colorado, Boulder (USA)

The possibility that common genetic factors regulate initial sensitivities to ethanol and nicotine as well as the development of cross-tolerance between these agents was explored using the long-sleep (LS) and short-sleep (SS) mice. The LS mice proved to be more sensitive to an acute challenge with nicotine than were the SS mice. Segregation analysis (F1, F2, backcross) indicated that ethanol sensitivity and nicotine sensitivity segregate together. Acute pretreatment with nicotine did not significantly affect sensitivity to ethanol, but ethanol pretreatment altered nicotine responsiveness. The LS mice develop more tolerance to nicotine and ethanol than do the SS and they also develop more cross-tolerance. These genetically determined differences in initial sensitivities, and tolerance and cross-tolerance development are not readily explained by differences in brain nicotinic receptor numbers.

• OSTI ID: 6807912
• Journal Information: Alcohol; (USA), Journal Name: Alcohol; (USA) Vol. 7:3; ISSN 0741-8329; ISSN ALCOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALKALOIDS
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
BODY TEMPERATURE
BRAIN
CENTRAL NERVOUS SYSTEM
DRUGS
ETHANOL
GENETIC VARIABILITY
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MICE
NERVOUS SYSTEM
NICOTINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
PROTEINS
PYRIDINES
PYRROLES
PYRROLIDINES
RECEPTORS
RODENTS
SLEEP
SYNERGISM
TOLERANCE
VERTEBRATES