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Development of Bromine-77 from the LAMPF facility

Technical Report ·
DOI:https://doi.org/10.2172/6806699· OSTI ID:6806699
;

The objective of the work is to conduct the necessary studies required to evaluate the efficacy, potential benefit and role of bromine-77 labelled steroids in the detection and evaluation of treatment for hormone-dependent tumors. The synthetic goals of 1982-3 included the synthesis estradiol derivatives which were radiohalogenated in the A- or C-ring with bromine-77 or bromine-82. Estradiol derivatives in which the radiohalogen was incorporated into the C-ring were prepared and purified with high specific activity. Biodistribution studies of the resultant compounds will be performed on rats in the near future. Various synthetic approaches toward estradiol which is radiohalogenated in the 1-position are discussed.

Research Organization:
New Mexico Univ., Albuquerque, NM (USA). School of Medicine
Sponsoring Organization:
DOE/ER
DOE Contract Number:
AS04-81EV10596
OSTI ID:
6806699
Report Number(s):
DOE/EV/10596-T3; ON: DE91000114
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550201 -- Biochemistry-- Tracer Techniques
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINATION
BROMINE 77
BROMINE 82
BROMINE ISOTOPES
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DETECTION
DISEASES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTRADIOL
ESTRANES
ESTROGENS
HALOGENATION
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAGNETIC RESONANCE
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MAGNETIC RESONANCE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PROGRESS REPORT
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RESONANCE
SPECTROSCOPY
STEROID HORMONES
STEROIDS
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
THERAPY
TOXICITY