Insulin resistance and delayed clearance of peptide hormones in cirrhotic rat liver

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Am. J. Physiol.; (United States)

OSTI ID:6801525

Shankar, T P; Drake, S; Solomon, S S

Clearance of porcine insulin, glucagon, and human growth hormone was measured in intact perfused cirrhotic and normal rat livers. Binding and degradation of /sup 125/I-insulin by hepatocytes isolated from cirrhotic and normal livers were also studied. The half-lives (t/sub 1/2/) of immunoreactive insulin and glucagon were 14.0 +/- 3.1 and 9.6 +/- 2.1 min in normal livers and 26.0 +/- 6.1 and 25.0 +/- 7.1 min in cirrhotic livers. Insulin binding and degradation by hepatocytes from control and cirrhotic livers showed no significant differences. Intraportal insulin infusion in perfusion studies suppressed glucagon-stimulated increases in glucose output from control livers but failed to suppress glucose production by cirrhotic livers, suggesting the presence of hepatic insulin resistance in cirrhosis. Impaired clearance of insulin and glucagon by the intact cirrhotic liver and normal binding and degradation of insulin by isolated hepatocytes suggest that factors such as intrahepatic fibrosis and shunting and postbinding defects may be responsible for the impaired hormone clearance and hepatic insulin resistance.

• Research Organization: Univ. of Tennessee, Memphis (USA)
• OSTI ID: 6801525
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:6; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIODEGRADATION
BIOLOGICAL FUNCTIONS
BODY
CARBOHYDRATES
CHEMICAL REACTIONS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
FIBROSIS
FUNCTIONS
GLANDS
GLUCAGON
GLUCOSE
HEXOSES
HORMONES
INJURIES
INSULIN
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
LIVER CELLS
LIVER CIRRHOSIS
MAMMALS
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PEPTIDE HORMONES
PEPTIDES
PERFUSED TISSUES
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
SACCHARIDES
SOMATIC CELLS
SWINE
TISSUES
VERTEBRATES