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Complications after proton beam therapy for uveal malignant melanoma. A clinical and histopathologic study of five cases

Journal Article · · Ophthalmology (Rochester, Minn.); (United States)
; ; ; ; ; ; ;
Proton beam therapy for uveal malignant melanoma has been advocated as effective therapy because of documented reduction in tumor size and few clinical complications. However, some eyes have been removed because of adverse effects. The authors report the clinical courses and pathologic findings of five eyes enucleated after proton beam irradiation. Neovascular glaucoma had developed in three eyes, two eyes had vitreous hemorrhage, and two had extraocular extension. The tumors in the radiation treatment field showed continued postirradiation growth clinically in four of the five eyes, and mitotic activity histologically in all five cases. Two and one half years after irradiation, and nearly 2 years after subsequent enucleation, one of those two patients had biopsy-proven liver metastases, and later died. Despite the considerable success rate of proton beam irradiation, the potential for clinical complications and subsequent tumor growth remains.
Research Organization:
Univ. of Texas Health Science Center, San Antonio (USA)
OSTI ID:
6797107
Journal Information:
Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 95:7; ISSN OPHTD
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CELL DIVISION
DISEASES
EYES
FACE
HEAD
HEMORRHAGE
INJURIES
MEDICINE
MELANOMAS
MITOSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
ORGANS
PARTICLE BEAMS
PATHOLOGICAL CHANGES
PATIENTS
PROTON BEAMS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SIDE EFFECTS
SYMPTOMS
THERAPY
UVEA