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Histopathology of uveal melanomas treated with charged particle radiation

Journal Article · · Ophthalmology (Rochester, Minn.); (United States)
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The authors have treated 255 uveal melanomas with helium ion radiation. Twenty-three eyes have been enucleated because of complications and five eyes have been obtained at autopsy. We have evaluated 27 of these eyes. Neovascular glaucoma (10 eyes), painful keratitis (6 eyes), continued tumor growth (4 eyes), and vitreous hemorrhage (2 eyes) were the major complications of treatment that led to enucleation. The degree of tumor necrosis correlated with the size, pigmentation, and anterior extent of the tumor. It did not correlate with the interval from irradiation or with the amount of tumor shrinkage. Mitotic figures were extremely rare in treated tumors, suggesting that the tumor cells have lost their ability to cycle.
Research Organization:
Univ. of California, San Francisco
OSTI ID:
6087733
Journal Information:
Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 94:6; ISSN OPHTD
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CELL CONSTITUENTS
CHARGED PARTICLES
CYTOPLASM
DISEASES
EYES
FACE
HEAD
HELIUM IONS
INJURIES
IONS
LIPIDS
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
OPHTHALMOLOGY
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SIDE EFFECTS
THERAPY
TUMOR CELLS
UVEA