Histopathology of uveal melanomas treated with charged particle radiation
The authors have treated 255 uveal melanomas with helium ion radiation. Twenty-three eyes have been enucleated because of complications and five eyes have been obtained at autopsy. We have evaluated 27 of these eyes. Neovascular glaucoma (10 eyes), painful keratitis (6 eyes), continued tumor growth (4 eyes), and vitreous hemorrhage (2 eyes) were the major complications of treatment that led to enucleation. The degree of tumor necrosis correlated with the size, pigmentation, and anterior extent of the tumor. It did not correlate with the interval from irradiation or with the amount of tumor shrinkage. Mitotic figures were extremely rare in treated tumors, suggesting that the tumor cells have lost their ability to cycle.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6087733
- Journal Information:
- Ophthalmology (Rochester, Minn.); (United States), Vol. 94:6
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
RADIOTHERAPY
SIDE EFFECTS
UVEA
CYTOPLASM
HELIUM IONS
LIPIDS
OPHTHALMOLOGY
RADIATION INJURIES
TUMOR CELLS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CELL CONSTITUENTS
CHARGED PARTICLES
DISEASES
EYES
FACE
HEAD
INJURIES
IONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOLOGY
SENSE ORGANS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)