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Postsynaptic location of acrylamide-induced modulation of striatal /sup 3/H-spiroperidol binding

Journal Article · · Neurotoxicology (Park Forest South, Ill.); (United States)
OSTI ID:6795277
; ; ; ;
The striata of rats were unilaterally lesioned with kainic acid. After two weeks, rats were exposed to 10 doses of acrylamide (20 mg/kg body weight/dose) over two weeks. Binding of /sup 3/H-spiroperidol to membranes prepared from unoperated striata, was elevated in acrylamide-exposed rats relative to undosed controls. This differential was not apparent when binding was compared in membranes from kainate-treated striata of acrylamide-treated and untreated rats. A parallel acrylamide treatment of unoperated rats had no significant effect on striatal levels of dihydroxyphenylacetic acid and homovanillic acid suggesting that this neurotoxicant failed to affect the presynaptic events of the dopamine system. Thus, the alterations of the striatal dopamine receptor caused by acrylamide, that have been previously reported, appear to be confined to postsynaptic sites.
Research Organization:
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
OSTI ID:
6795277
Journal Information:
Neurotoxicology (Park Forest South, Ill.); (United States), Journal Name: Neurotoxicology (Park Forest South, Ill.); (United States) Vol. 3:1; ISSN NRTXD
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
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59 BASIC BIOLOGICAL SCIENCES
ACRYLAMIDE
AMIDES
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CELL CONSTITUENTS
CELL MEMBRANES
CHEMISTRY
DRUGS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
NERVE CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHYSIOLOGY
RATS
RECEPTORS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES