Development of neuropeptide Y (NPY) immunoreactive neurons in the rat occipital cortex: A combined immunohistochemical-autoradiographic study
- University College London (England)
The postnatal development of neuropeptide Y (NPY)-immunoreactive neurons, previously labeled with (3H)thymidine on embryonic days E14-E21, has been studied in the rat occipital cortex. Immunohistochemistry combined with autoradiography showed evidence of a modified inside-out pattern of maturation. NPY-neurons are generated between E14 and E20 and are found in layers II-VI of the cortex and the subcortical white matter. NPY neurons from all these birthdates are overproduced at first, although cells generated at E16 produce the greatest excess, followed by E15 and E17. Some of these transient neurons are found in the wrong layer for their birthdates, and their elimination produces a more correct alignment at maturity. However, most of the NPY neurons that survive are generated at E17, and these cells are found throughout layers II-VI with a preponderance in layer VI. This evidence is strongly suggestive of cell death rather than merely cessation of production of NPY.
- OSTI ID:
- 6794421
- Journal Information:
- Journal of Comparative Neurology; (USA), Vol. 297:4; ISSN 0021-9967
- Country of Publication:
- United States
- Language:
- English
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THYMIDINE
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AZINES
BODY
CENTRAL NERVOUS SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
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RIBOSIDES
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550301* - Cytology- Tracer Techniques