Integration of chemotherapy into a combined modality treatment plan for head and neck cancer: a review

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90442-9· OSTI ID:6794219

Glick, J H ^[1]; Taylor, S G

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1. Univ. of Pennsylvania, Philadelphia

This review highlights the most important recent advances in the chemotherapeutic management of patients with squamous cell carcinoma of the head and neck. In patients who have recurrent or metastatic disease, methotrexate, platinum, and bleomyc are three active drugs when used as single agents. There is no evidence that high-dose methotrexate therapy is superior to more conventional weekly intravenous methotrexate in the treatment of recurrent disease. Platinum is a new agent that has demonstrated activity against hematogenous as well as regional disease. In the absence of evidence of a dose-response curve for platinum, the lower dosage schedules sould be used that can be given with acceptable toxicity on an outpatient basis. Combination chemotherapy has resulted in a high proportion of objective responders and approximately 20% complete remissions to any of several platinum-containing regimens. However, the median duration of response remains short and none of the combination drug programs has been established as yet as superior to single agent chemotherapy in a randomized trial.

• OSTI ID: 6794219
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BLEOMYCIN
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
DISEASES
DOCUMENT TYPES
DRUGS
ELEMENTS
HEAD
MEDICINE
METALS
METHOTREXATE
NECK
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
PLATINUM
PLATINUM METALS
RADIOLOGY
RADIOTHERAPY
REVIEWS
SURGERY
SYNERGISM
THERAPY
TRANSITION ELEMENTS