Synthesis of 6-(F-18)L-fluoro-dopa using F-18 labelled acetyl hypofluorite
The synthesis of (F-18)6-fluoro-dopa via acetyl hypofluorite has recently been reported. The authors have modified this procedure by adding an acetate protecting group on the dopa ring and have treated this new starting material with either solution or gas phase F-18 acetyl hypofluorite. Using this starting material the yield has been significantly increased over the published method. The authors routinely prepare 4-5 mCi of pure (F-18)6-fluoro-dopa (3-4% radiochemical yield, at EOS) in an overall synthesis time of 2 hours. Both 2 and 6 fluoro-dopa are produced in nearly equivalent amounts by this method as determined by /sup 19/F nmr. These are easily separated by HPLC after deblocking with HI. The final isolated product is >99% in the L-isomer form and fluorinated in >97% in the 6 position.
- Research Organization:
- TRIUMF/UBC Program on Positron Emission Tomography, Univ. of British Columbia, Vancouver
- OSTI ID:
- 6793858
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400700 -- Radiochemistry & Nuclear Chemistry
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETATES
ACETYL RADICALS
ACYL RADICALS
ALKALINE EARTH METAL COMPOUNDS
AMINO ACIDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CALCIUM COMPOUNDS
CALCIUM FLUORIDES
CALCIUM HALIDES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHEMICAL REACTIONS
CHEMISTRY
CHROMATOGRAPHY
DOPA
DRUGS
FLUORIDES
FLUORINATION
FLUORINE 18
FLUORINE 19
FLUORINE COMPOUNDS
FLUORINE ISOTOPES
FLUORITE
HALIDE MINERALS
HALIDES
HALOGEN COMPOUNDS
HALOGENATION
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MINERALS
NEUROREGULATORS
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADICALS
RADIOACTIVITY
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TIME DEPENDENCE
TRACER TECHNIQUES
YIELDS