Difference in the ratio of dominant-lethal mutations to heritable translocations produced in mouse spermatids and fully mature sperm after treatment with triethylenemelamine (TEM)

Journal Article · Thu Apr 01 04:00:00 EST 1982 · Genetics; (United States)

OSTI ID:6793338

Generoso, W M; Cain, K T; Cornett, C V; Russell, E W; Hellwig, C S; Horton, C Y

The relative induction of dominant-lethal mutations and heritable translocations in triethylenemelamine-treated male postmeiotic germ cells of mice was determined depending on the stage treated. Males were mated either 11.5 to 14.5 days after treatment (middle spermatids) or less than 2.5 hours after treatment (fully mature sperm). Results clearly showed that, even though similar levels of dominant-lethal mutations were induced in fully mature sperm and in middle spermatids, the frequency of heritable translocations induced in mature sperm was markedly lower than that induced in middle spermatids. This observation was used, together with earlier ones, to suggest a mechanism by which dominant-lethal mutations and heritable translocations are produced following chemical treatment of male postmeiotic germ cels.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6793338
• Journal Information: Genetics; (United States), Journal Name: Genetics; (United States) Vol. 100; ISSN GENTA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
BIOLOGICAL EFFECTS
DATA
ESTERS
EXPERIMENTAL DATA
GAMETES
GAMETOGENESIS
GENES
GENETIC EFFECTS
GERM CELLS
INFORMATION
LETHAL GENES
LITTER SIZE
MAMMALS
MICE
MUTATIONS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
SPERMATOGENESIS
SPERMATOZOA
SULFONIC ACID ESTERS
TIME DEPENDENCE
VERTEBRATES
VIABILITY