Relative rates at which dominant-lethal mutations and heritable translocations are induced by alkylating chemicals in postmeiotic male germ cells of mice

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · Genetics; (United States)

OSTI ID:5577173

Generoso, W M; Huff, S W; Cain, K T

There is a close relationship between the rates at which dominant lethal mutations and heritable translocations are induced by ethyl methanesulfonate (EMS) or triethylenemelamine (TEM) in male postmeiotic germ cells. This relationship does not hold for isopropyl methanesulfonate (IMS), which induced only negigible frequencies of heritable translocations at doses that induced high levels of dominant lethal mutations. Nor does IMS behave like EMS and TEM in the degree to which eggs of different stocks of females repair premutational lesions that are carried in the sperm - large differences between stocks for IMS treatment and small differences for EMS or TEM treatment. These dissimilarities between IMS and the other two alkylating chemicals are postulated to be attributable to differences in the types of lesions present at the time of repair activity and to whether or not chromosomal aberrations are already fixed prior to postfertilization pronuclear DNA synthesis.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 5577173
• Journal Information: Genetics; (United States), Journal Name: Genetics; (United States) Vol. 93:1; ISSN GENTA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
ANTIMITOTIC DRUGS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
CHROMOSOMAL ABERRATIONS
DNA
DOMINANT MUTATIONS
DOSES
DRUGS
EMS
ESTERS
GAMETES
GERM CELLS
KINETICS
LETHAL MUTATIONS
MALES
MAMMALS
MICE
MUTAGENESIS
MUTAGENS
MUTATION FREQUENCY
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
REACTION KINETICS
RECOVERY
REPAIR
RODENTS
SPERMATOZOA
SULFONIC ACID ESTERS
SYNTHESIS
TOXICITY
VERTEBRATES