Repair in fertilized eggs of mice and its role in the production of chromosomal aberrations. [Comparison of the effects of the chemical mutagens EMS, IMS, and TEM with the physical mutagen x rays]

Conference · Mon Jan 01 04:00:00 EST 1979

OSTI ID:6132616

Generoso, W M

The fertilized egg may influence the yield of dominant-lethal mutations produced from chemical treatment of male postmeiotic germ cells to a small or large extent depending upon the mutagen used and the competence of the egg to repair the premutational lesions induced. The strain of females has small influence on the yield of dominant-lethal mutations induced by TEM or EMS in spermatids and spermatozoa. On the contrary, it has large influence in the case of IMS. In addition to this difference, TEM and EMS induce high levels of heritable translocations at these germ cell stages while IMS is practically ineffective even though doses of these chemicals used produced comparable levels of dominant-lethal mutations. These differences between EMS and TEM on one hand and IMS on the other, were explained as a function of the types of chromosomal lesions present at the time of repair activity and whether or not chromosomal aberrations are already fixed at the time of postfertilization pronuclear DNA synthesis.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: Not Available; USDOE
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6132616
• Report Number(s): CONF-790676-2
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMOSOMAL ABERRATIONS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOMINANT MUTATIONS
DRUGS
ELECTROMAGNETIC RADIATION
EMS
ESTERS
EXPERIMENTAL DATA
FEMALES
FERTILIZATION
GAMETES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GERM CELLS
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL MUTATIONS
MALES
MAMMALS
MICE
MUTAGENESIS
MUTAGENS
MUTATIONS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OVA
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SPERMATOZOA
SULFONIC ACID ESTERS
VERTEBRATES
X RADIATION