A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging
- Squibb Institute for Medical Research, New Brunswick, NJ (USA)
Technetium-99m-DMG-2MP (Chloro(bis(2,3-butanedionedioxime(1-)-0)(2,3- butanedionedioximato (2-)-N,N{prime},N{double prime},N{prime}{double prime},N{double prime}{double prime},N{prime}{double prime}{double prime}) (2-methylpropyl borato (2-))technetium)), also known as SQ 32097 is a member of a family of neutral lipophilic compounds generally known as boronic acid adducts of technetium dioxime complexes (BATOs). After i.v. administration, the concentration of ({sup 99m}Tc)DMG-2MP in various regions of the brain appears to be proportional to blood flow. In rats, 1.1% ID was in the brain at 5 min postinjection when the blood contained less than 3% ID. Over 24 hr excretion was 59% in the feces and 23% in the urine. The activity in monkey brain at 5 min was 2.8% ID and it cleared with a t1/2 of 86 min. Autoradiographs of monkey brain sections showed excellent regional detail with a gray/white ratio of 3.6 at 10 min. The distribution of ({sup 99m}Tc)DMG-2MP in the monkey brain corresponds to the known cytoarchitectural pattern of cerebral glucose metabolism. The properties of ({sup 99m}Tc)DMG-2MP make it a potentially useful agent for cerebral perfusion imaging in man.
- OSTI ID:
- 6793220
- Journal Information:
- Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:8; ISSN 0161-5505; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Relationship between in vitro transendothelial permeability and in vivo single-pass brain extraction
Characterization of technetium-99m-L,L-ECD for brain perfusion imaging, Part 1: Pharmacology of technetium-99m ECD in nonhuman primates
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DISTRIBUTION
DRUGS
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONKEYS
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PERFUSED ORGANS
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SACCHARIDES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES