Characterization of technetium-99m-L,L-ECD for brain perfusion imaging, Part 1: Pharmacology of technetium-99m ECD in nonhuman primates

Journal Article · Tue Oct 31 23:00:00 EST 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5101331

Walovitch, R C; Hill, T C; Garrity, S T; Cheesman, E H; Burgess, B A; O'Leary, D H; Watson, A D; Ganey, M V; Morgan, R A; Williams, S J ^[1]

---

1. E.I. Du Pont de Nemours Co., Inc., No. Billerica, MA (USA)

Technetium-99m ethyl cysteinate dimer (({sup 99m}Tc)ECD) is a neutral, lipophilic complex which rapidly crosses the blood-brain barrier. Brain retention and tissue metabolism of ({sup 99m}Tc)ECD is dependent upon the stereochemical configuration of the complex. While both L,L and D,D enantiomers are extracted by the brain, only the L,L but not the D,D form, is metabolized and retained in the monkey brain (4.7% injected dose initially, T 1/2 greater than 24 hr). Dynamic single photon emission computed tomography imaging studies in one monkey indicates {sup 99m}Tc-L,L-ECD to be distributed in a pattern consistent with regional cerebral blood flow for up to 16 hr postinjection. Dual-labeled {sup 99m}Tc-L,L-ECD and ({sup 14}C)iodoantipyrine autoradiography studies performed 1 hr after administration show cortical gray to white matter ratios of both isotopes to be equivalent (approximately 4-5:1). These data suggest that {sup 99m}Tc-L,L-ECD will be useful for the scintigraphic assessment of cerebral perfusion in humans.

• OSTI ID: 5101331
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 30:11; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTORADIOGRAPHY
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
COMPLEXES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOUBLE LABELLING
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ISOMERIC NUCLEI
ISOTOPE RATIO
LABELLED COMPOUNDS
LABELLING
MAMMALS
METABOLISM
MONKEYS
NERVOUS SYSTEM
NUCLEI
ORGANS
PERFUSED ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES