Absorption of methylmercury by the fetal guinea pig during mid to late gestation

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Teratology; (United States)

DOI:https://doi.org/10.1002/tera.1420210205· OSTI ID:6791454

Kelman, B J; Steinmetz, S E; Walter, B K; Sasser, L B

Pregnant guinea pigs were injected with CH/sub 3/ /sup 203/HgCl at 22, 40, 47, 59, and 66 days of gestation, and fetal tissues were obtained 24 hours later. Autologous fetal erythrocytes were labeled with /sup 51/Cr and used to label the fetal blood pool at each gestational age except 22 days so that tissue-bound Hg could be calculated. In general, Hg absorbed by the whole fetus increased during gestation, in parallel with increasing tissue mass, while Hg found in whole placentas remained the same. Liver, kidney, blood, and brain contained the highest Hg concentration early in gestation. While it is difficult to interpret the potential effects of the increased Hg concentrations, particular attention should be paid to the brain, since it is considered a target tissue in MeHg toxicity.

• Research Organization: Comparative Animal Research Lab., Oak Ridge, TN
• OSTI ID: 6791454
• Journal Information: Teratology; (United States), Journal Name: Teratology; (United States) Vol. 21; ISSN TJADA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
FETUSES
GLANDS
GUINEA PIGS
HEAVY NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LIVER
MAMMALS
MATERIALS
MERCURY 203
MERCURY ISOTOPES
METHYLMERCURY
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
TIME DEPENDENCE
VERTEBRATES