Polycyclic aromatic primary amines as determinant chemical mutagens in petroleum substitutes

Journal Article · Wed Oct 01 04:00:00 EDT 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90092-4· OSTI ID:6791243

Guerin, M R; Ho, C; Rao, T K; Clark, B R; Epler, J L

Petroleum crude oils and coal- and shale-derived petroleum substitutes have been separated by chemical class and the class fractions have been subjected to bacterial mutagenicity testing. Alkaline constituents of the petroleum substitutes are found to make major contributions to their mutagenicities. High-resolution chromatographic and spectroscopic analysis of alkaline subfractions enriched in mutagenic activity show the causative agents to be polycyclic aromatic primary amines. The amines may be responsible for the increased biological activity of coal- and shale-derived petroleum substitutes relative to petroleum.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6791243
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 23:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
550700 -- Microbiology
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AROMATICS
BACTERIA
CHEMICAL ANALYSIS
CHROMATOGRAPHY
COAL LIQUIDS
DATA
ENERGY SOURCES
EXPERIMENTAL DATA
FLUIDS
FOSSIL FUELS
FUELS
GAS CHROMATOGRAPHY
HYDROCARBONS
INFORMATION
LIQUIDS
MASS SPECTROSCOPY
MICROORGANISMS
MINERAL OILS
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PETROLEUM
POLYCYCLIC AROMATIC HYDROCARBONS
QUALITATIVE CHEMICAL ANALYSIS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEPARATION PROCESSES
SHALE OIL
SPECTROSCOPY
SYNTHETIC FUELS
SYNTHETIC PETROLEUM